Through the Regional Hub Network, AFRL scientists and engineers engage and collaborate with universities, small and large businesses, other government agencies and venture capitalists to assemble a new science and technology ecosystem in which partners help the lab research high-risk case studies. The goals of this collaboration are to leverage research, translation and workforce development successes across the United States, encourage science and technology exchanges and drive innovation.

In February 2022, Purdue was selected as one of two lead universities in the country and headquarter locations for the AFRL Regional Hub Network. A ribbon-cutting ceremony on April 21, 2023, officially made Purdue home to the AFRL Regional Hub Network - Midwest, which includes more than 60 academic and industrial partners from across 12 Midwest states. Cornell University is the academic lead and headquarters location for the AFRL Regional Research Hub - Mid-Atlantic.

Purdue's hub will host space for AFRL staff members to work on special projects that further research efforts and national security for the U.S.

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